Evelyn Wong

70 · female · Hypertension, Osteoarthritis pain, Neuropathic pain, Coronary artery disease, High cholesterol

Medicines

Likely cascade links

Could be avoidable

Anticholinergic burden

Drugs toward falls

Dangerous combos

Root drug · likely · score 0.54

Amitriptyline → 3 downstream

Amitriptyline

Tricyclic antidepressant

Midodrine

Oral vasopressor

Chlorthalidone

Thiazide diuretic

Colchicine

Gout flare treatment

Root drug · likely · score 0.92

Chlorthalidone

Thiazide diuretic

Colchicine

Gout flare treatment

Loperamide

Antidiarrhoeal

Why Domino thinks so

Amitriptyline started Jan 24, 2024 · Midodrine started Mar 6, 2024

0.74

likely

How often it causes this×0.7Orthostatic hypotension is common with Amitriptyline.

Timing×1Midodrine started 6 weeks after Amitriptyline, inside the usual window for orthostatic hypotension (1 to 60 days).

Other reasons×1.25Midodrine was charted for orthostatic hypotension.

Published evidence×0.85Not a documented pattern: inferred from the graph alone.

Teach Domino. Your decision becomes memory every future review respects.

Checked and set aside

Analysis: 10 FalkorDB queries, run in parallel, 24 ms