72 · female · Dry cough, Hypertension, Osteoarthritis pain, Atrial fibrillation, Coronary artery disease, Depression, Osteoporosis
Root drug · likely · score 0.84
Also feeding this chain: Chlorthalidone → low potassium → Spironolactone (possible, 0.30).
Root drug · likely · score 0.99
Feedback loop
Chlorthalidone can cause gout / hyperuricaemia, which Naproxen treats; Naproxen can cause hypertension, which Chlorthalidone treats. Each drug can feed the problem the other is treating.
Why Domino thinks so
Naproxen started Mar 30, 2024 · Valsartan started May 26, 2024
NSAID → high blood pressure → antihypertensive
Evidence: expert consensus
Not confirmed in the Irish national data (a significant negative association).
Question for the pharmacist: Could the raised blood pressure be from the NSAID? NSAIDs raise blood pressure and blunt most antihypertensives.
Teach Domino. Your decision becomes memory every future review respects.
Checked and set aside
Analysis: 10 FalkorDB queries, run in parallel, 27 ms