Arthur Russo

87 · male · Type 2 diabetes, Heart failure, High cholesterol

Pharmacist brief Check a new prescription Export FHIR

Medicines

Likely cascade links

Could be avoidable

Anticholinergic burden

Drugs toward falls

Dangerous combos

Root drug · likely · score 0.56

Furosemide → 2 downstream

Furosemide

Loop diuretic

Mirabegron

Beta-3 agonist

Doxazosin

Alpha-1 blocker

Why Domino thinks so

Furosemide → leaking urine, urgency → Mirabegron

Furosemide started Jul 27, 2024 · Mirabegron started Oct 24, 2024

0.99

likely

How often it causes this×0.7Urinary incontinence is common with Furosemide.

Timing×1Mirabegron started 13 weeks after Furosemide, inside the usual window for urinary incontinence (1 to 90 days).

Other reasons×1.25Mirabegron was charted for urinary incontinence.

Published evidence×1.2Matches a documented cascade backed by expert consensus (ThinkCascades).

Diuretic → urinary incontinence → bladder medication

Evidence: expert consensus

Not confirmed in the Irish national data (a significant negative association).

Question for the pharmacist: Could the urgency or leaking be from the diuretic? Changing the timing of the dose can help before adding a bladder medication.

Teach Domino. Your decision becomes memory every future review respects.

Checked and set aside

Analysis: 10 FalkorDB queries, run in parallel, 17 ms