Omar Tremblay

87 · male · Atrial fibrillation, High cholesterol, Enlarged prostate (BPH), Anxiety

Medicines

Likely cascade links

Could be avoidable

Anticholinergic burden

Drugs toward falls

Dangerous combos

Root drug · likely · score 0.99

Lorazepam → 1 downstream

Lorazepam

Benzodiazepine

Galantamine

Cholinesterase inhibitor

Root drug · likely · score 0.74

Simvastatin

Statin

Ibuprofen

NSAID

Why Domino thinks so

Lorazepam started Feb 12, 2024 · Galantamine started May 20, 2024

0.99

likely

How often it causes this×0.7Cognitive impairment is common with Lorazepam.

Timing×1Galantamine started 3 months after Lorazepam, inside the usual window for cognitive impairment (7 to 180 days).

Other reasons×1.25Galantamine was charted for cognitive impairment.

Published evidence×1.2Matches a documented cascade backed by expert consensus (ThinkCascades).

Benzodiazepine → memory problems → dementia medication

Evidence: expert consensus

Not confirmed in the Irish national data (a significant negative association).

Question for the pharmacist: Could the memory problems be from the benzodiazepine? Benzodiazepines impair memory and attention in older adults.

Teach Domino. Your decision becomes memory every future review respects.

Checked and set aside

Analysis: 10 FalkorDB queries, run in parallel, 18 ms