91 · male · Osteoarthritis pain, Atrial fibrillation
His painkiller raised his blood pressure. The fix gave him gout.
Root drug · likely · score 0.96
Feedback loop
Hydrochlorothiazide can cause gout / hyperuricaemia, which Naproxen treats; Naproxen can cause hypertension, which Hydrochlorothiazide treats. Each drug can feed the problem the other is treating.
Why Domino thinks so
Naproxen started Apr 10, 2024 · Hydrochlorothiazide started Jun 12, 2024
NSAID → high blood pressure → antihypertensive
Evidence: expert consensus
Not confirmed in the Irish national data (a significant negative association).
Question for the pharmacist: Could the raised blood pressure be from the NSAID? NSAIDs raise blood pressure and blunt most antihypertensives.
Teach Domino. Your decision becomes memory every future review respects.
Checked and set aside
Analysis: 10 FalkorDB queries, run in parallel, 21 ms