84 · female · Hypertension, Osteoarthritis pain, High cholesterol
Nine medications. One of them started four of the others.
Root drug · likely · score 0.96
Also feeding this chain: Naproxen → ankle and leg swelling → Furosemide (possible, 0.45).
Feedback loop
Donepezil can cause urinary incontinence, which Oxybutynin treats; Oxybutynin can cause cognitive impairment, which Donepezil treats. Each drug can feed the problem the other is treating.
Why Domino thinks so
Amlodipine started Apr 30, 2024 · Furosemide started Jun 17, 2024
Calcium channel blocker → ankle swelling → diuretic
Evidence: expert consensus
Real-world signal: adjusted sequence ratio 1.93 (95% CI 1.79–2.09), found in 2.6% of Ireland, 533,464 adults aged 65+.
Question for the pharmacist: Could the ankle swelling be from the calcium channel blocker? CCB edema does not respond well to diuretics; a dose change or a different antihypertensive may help instead.
Teach Domino. Your decision becomes memory every future review respects.
Checked and set aside
Analysis: 10 FalkorDB queries, run in parallel, 26 ms